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Science you trust. Beauty you can see.
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Triple Activated MSCs derived exosome elevate Collagen 1 Production in Human Fibroblasts: PGUS’s Triple Activated MSCs derived exosomes significant increase in Collagen I synthesis compared to the non-activated exosomes from Conditional Medium. Both intracellular and secreted collagen fractions were elevated (normalized to total protein), confirming that activated MSC exosomes enhance fibroblast function and extracellular matrix production—a key mechanism underlying skin rejuvenation and wound healing.
Key Benefits:
- Promotes cellular regeneration for smoother, youthful skin
- Reduces the appearance of fine lines, wrinkles, and pigmentation
- Enhances skin’s elasticity and firmness
- Deeply hydrates and revitalizes for a glowing complexion
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At Étrive™, every step of development is guided by international cosmetic safety standards and strict quality control.
- Regulatory Support: Our raw materials are backed by multiple FDA Master Files (MF), including MF No. 30241 (GMP-grade raw material) and MF No. 17799 (GMP Expansion Media), demonstrating compliance with globally recognized quality frameworks.
- GMP-Aligned Standards: All production processes follow GMP principles in certified facilities, ensuring consistency and safety from sourcing to final product.
- Purity & Consistency: Each batch undergoes multi-step purification and rigorous testing to ensure the highest level of purity and reproducibility.
- Formulated for All Skin Types: Gentle yet effective, Étrive™ solutions are designed to be suitable for diverse skin types, minimizing risk of irritation.
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“After one treatment, wrinkles appeared visibly softened, and the skin looked and felt noticeably smoother, with a soft, silky feel to the touch.”
*Based on internal product testing and visual evaluation. Individual results may vary.
Étrive supports the natural beauty your skin already knows.
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A refinement system designed to achieve a level of activity consistency and formulation uniformity that conventional approaches cannot easily replicate.
While conventional products may rely on non-activated components, Étrive™M formulations are produced through a multi-stage refinement system, delivering not only superior purity but also amplified activity in greater abundance.
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Etrive™ Gold – Lyophilized Aesthetic Solution
Etrive™ Gold Lyophilized Aesthetic Solution is formulated with nutrient extracts combined with naturally derived cosmetic ingredients, enhanced through DERMA-fresEXO™ technology to provide gentle yet effective care for regular beauty routines.
- Key Advantage — EV complex with nutrient medium extract for enhanced cosmetic benefits
- Cosmetic Benefits — Enhances skin’s appearance, improves the look of texture, and helps maintain a smooth, refined look against environmental stressors
- Specification — Each dual-chamber system contains 1 billion lyophilized EV complex + 5 mL
cosmetic solution - For cosmetic, topical use only
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Étrive’s exosome is different when compared with all other exosome products in the marketplace.
- Étrive’s Triple Actived MSC derived exosome has much better safety standard and potency in skin care applications, which include wound healing and tissue regeneration. It also has significant safer delivery methods as compared with most other exosome product in the market.
- Most of the exosomes in the market require microneedling. Because microneedling creates micro-injuries that trigger a natural healing response, and exosomes deliver potent growth factors, proteins, and peptides directly into these channels to enhance the body’s natural processes, leading to faster healing, more collagen production, and improved skin texture and tone. However, Étrive does not depend on any additional treatment to work.
- Étrive’s exosome does not require microneedling or other types of invasive methods to help the exosome penetrate the skin. PrimeGen US has tested the delivery method of the Étrive exosome. After cleaning the surface of the face, apply the serum on the face, the beautician uses rubber gloves to rub the exosome serum into the skin. It takes 10 to 13 minutes to rub the whole face. The exosome is then Instantly absorbed.
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How Étrive’s Triple Activated MSC derived exosome helps regenerate fibroblast tissue.
- Exosomes deliver signals that promote the proliferation and migration of fibroblasts, as well as other skin cells like keratinocytes. This increased cell activity is crucial for tissue repair and regeneration.
- Etrive’s Triple Activated MSC derived exosome carries a signal message to the fascial fibroblast to instruct them to release enzyme and cytokines such as CD73 to control facial fibroblast inflammation, Growth Factors for cell regeneration and repair the cells, and produce Collagen 1 to support the facial fibroblast extracellular matrix (ECM) structure.
- These facial fibroblast cells are vital for maintaining the skin’s structure and function by creating fibrous connective tissue that anchors the skin to the body.
- Étrive exosome can induce the facial fibroblast to regenerate itself back to the younger stage. Immediately after treatment the skin feels softer. That is the difference of the Étrive exosome as compared to all others facial treatment in the market.
- Étrive exosome products do not need to performed with facial injections to inject foreign elements into the skin to support the facial fibroblast matrix structure. It is because the Étrive exosome instructs the facial fibroblast to self-produce those important elements. It is all natural. It is part of your own facial fibroblast regeneration process.